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LET'S GET GENETICAL


It is possible to get many things at the Four Seasons Hotel in Westlake Village, Calif., but a blood-and-urine panel that analyzes the condition of your DNA is a relatively new development. The panel, offered through the California WellBeing Institute as part of several luxury-lifestyle packages, including a $2,800 executive physical, is boomingly popular: about 50 people signed up in January, the first month it was available.

Four years out from the sequencing of the human genome, DNA has become like the rain forest. Rummage around enough, one suspects, and you can eventually find the source of anything, be it heart-disease risk or unflattering frown lines. But even as research scientists struggle to catalog this elaborate ecosystem, companies selling the promise of genetically customized treatments have rolled out the tent and set up shop. . . .

There is little proof that such personalized products can make a difference for your health. But it makes sense that they might. Indeed, the general idea ¡Ö that thousands of subtle variations in our genetic functions affect both our health and how we age ¡Ö is broadly accepted. And while some of these variables may be innate ¡Ö about half of us carry a minor permutation that hampers our ability to metabolize folic acid, for instance ¡Ö others are simple wear and tear: the result of years of exposure to all the things that can cause DNA to break down, a long list that includes, but isn't limited to, cigarette smoke, sunburn, weed killer, coffee, antibiotics, neoprene and charcoal-grilled steak.

In theory, knowing how these changes in genetic production affect our overall health could enable us to correct for them.

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